Top 100 Largest Cities in the United States

by btobers · Published September 29, 2024 · Updated September 29, 2024

The United States is home to some of the most dynamic and diverse cities in the world. Each city has its unique charm, history, and cultural significance. From the bustling streets of New York City to the tech-savvy Silicon Valley, these urban centers are hubs of economic activity, education, and innovation. This page provides an overview of the top 20 cities in the U.S., highlighting their key landmarks, universities, and major highways. Whether you are planning a visit, considering relocation, or simply curious, this comprehensive guide offers a snapshot of what makes each city special.

1. New York City, New York

New York City, located in the northeastern U.S., is the largest city in the country. It is composed of five boroughs: Manhattan, Brooklyn, Queens, The Bronx, and Staten Island. Major landmarks include the Statue of Liberty, a symbol of freedom; Central Park, an expansive green oasis in the middle of Manhattan; Times Square, known for its bright lights and Broadway theaters; and the Empire State Building, an iconic skyscraper offering stunning city views. Renowned universities such as New York University (NYU) and Columbia University call this city home. Key highways include Interstates 78, 80, 87, and 95, which connect NYC to other major cities and regions.

2. Los Angeles, California

Los Angeles, situated in Southern California, is the entertainment capital of the world, home to Hollywood. Landmarks include the Hollywood Sign, a globally recognized symbol of the entertainment industry; Griffith Observatory, offering panoramic views of the city and the stars; and the Getty Center, known for its impressive architecture and art collections. Prominent universities include the University of California, Los Angeles (UCLA) and the University of Southern California (USC). Major highways include Interstates 5, 10, and 405, providing crucial links throughout the sprawling city.

3. Chicago, Illinois

Chicago, located on the southwestern shore of Lake Michigan, is famed for its impressive architecture and vibrant arts scene. Key landmarks include Willis Tower, once the tallest building in the world; Millennium Park, featuring the famous “Bean” sculpture; and the Art Institute of Chicago, which houses a vast collection of artworks. The University of Chicago and Northwestern University are top academic institutions. Major highways include Interstates 55, 90, and 94, which facilitate travel within and beyond the city.

4. Houston, Texas

Houston, in Southeast Texas, is known for its energy industry, space exploration, and diverse population. Landmarks include the Space Center Houston, a hub for NASA’s astronaut training and flight control; the Houston Museum of Natural Science, showcasing extensive exhibits on natural history; and the Houston Zoo. Major universities include the University of Houston and Rice University. Key highways include Interstates 10, 45, and 69, connecting Houston to other parts of Texas and the U.S.

5. Phoenix, Arizona

Phoenix, located in the southwestern U.S., is the state capital and known for its desert climate. Landmarks include Camelback Mountain, popular for hiking; the Desert Botanical Garden, featuring diverse desert plant life; and the Heard Museum, dedicated to Native American cultures. Arizona State University, one of the largest public universities in the U.S., is located here. Major highways include Interstates 10 and 17, which connect Phoenix to other key destinations.

6. Philadelphia, Pennsylvania

Philadelphia, in the northeastern U.S., is rich in American history. Key landmarks include the Liberty Bell, a symbol of American independence; Independence Hall, where the Declaration of Independence and Constitution were debated and adopted; and the Philadelphia Museum of Art, known for its “Rocky Steps.” The University of Pennsylvania and Temple University are major educational institutions. Key highways include Interstates 76, 95, and 676, which facilitate travel in and around the city.

7. San Antonio, Texas

San Antonio, located in South-Central Texas, blends rich history with modern attractions. Landmarks include the Alamo, a historic site from the Texas Revolution; the River Walk, a network of walkways along the San Antonio River; and the San Antonio Missions National Historical Park. The University of Texas at San Antonio and Trinity University are key universities. Major highways include Interstates 10, 35, and 37, which connect San Antonio to other major Texas cities.

8. San Diego, California

San Diego, situated in Southern California, is known for its beaches and parks. Major landmarks include Balboa Park, home to numerous museums and the San Diego Zoo; the USS Midway Museum, housed in a historic aircraft carrier; and La Jolla Cove, a picturesque coastal area. The University of California, San Diego (UCSD) is a leading research university. Major highways include Interstates 5, 8, and 15, providing critical links to other parts of California and beyond.

9. Dallas, Texas

Dallas, located in North Texas, is a major commercial and cultural hub. Key landmarks include the Sixth Floor Museum at Dealey Plaza, chronicling the assassination of President John F. Kennedy; the Dallas Arboretum and Botanical Garden; and the Dallas Museum of Art. Southern Methodist University (SMU) and the University of Texas at Dallas (UTD) are prominent universities. Major highways include Interstates 20, 30, and 35E, facilitating travel across the Dallas-Fort Worth metroplex.

10. San Jose, California

San Jose, in the heart of Silicon Valley, is a major technology hub. Landmarks include the Tech Museum of Innovation, showcasing technological advancements; the Winchester Mystery House, known for its peculiar architecture; and Santana Row, a popular shopping and dining destination. Stanford University and San Jose State University are key academic institutions. Major highways include Interstates 280, 680, and 880, providing important connections within the Bay Area.

11. Austin, Texas

Austin, the capital of Texas, is renowned for its live music scene and vibrant culture. Landmarks include the Texas State Capitol, a historic building with guided tours; Zilker Park, a large urban park hosting events like the Austin City Limits Music Festival; and Barton Springs Pool, a natural spring-fed swimming pool. The University of Texas at Austin is a major research university. Key highways include Interstates 35 and 45, connecting Austin to other major Texas cities.

12. Jacksonville, Florida

Jacksonville, situated in Northeast Florida, is the largest city by area in the contiguous U.S. Key landmarks include the Jacksonville Zoo and Gardens, featuring over 2,000 animals; the Cummer Museum of Art and Gardens, known for its art collection and scenic gardens; and the Riverside Arts Market. The University of North Florida (UNF) is a major institution. Major highways include Interstates 10 and 95, connecting Jacksonville to other parts of Florida and the southeastern U.S.

13. Fort Worth, Texas

Fort Worth, part of the Dallas-Fort Worth metroplex, is known for its Western heritage and vibrant cultural scene. Landmarks include the Fort Worth Stockyards, a historic district celebrating the city’s cattle industry; the Kimbell Art Museum, housing a renowned art collection; and the Fort Worth Zoo. Texas Christian University (TCU) is a key academic institution. Major highways include Interstates 20, 30, and 35W, which facilitate travel within the metroplex and beyond.

14. Columbus, Ohio

Columbus, the state capital of Ohio, is known for its diverse economy and cultural institutions. Key landmarks include the Ohio Statehouse, a historic government building; Franklin Park Conservatory and Botanical Gardens, featuring diverse plant collections; and the Columbus Zoo and Aquarium. The Ohio State University, one of the largest universities in the U.S., is located here. Major highways include Interstates 70 and 71, connecting Columbus to other major cities in Ohio and the Midwest.

15. Charlotte, North Carolina

Charlotte, in the southeastern U.S., is a major financial hub. Key landmarks include the NASCAR Hall of Fame, celebrating the sport’s history; Carowinds, an amusement park straddling the North Carolina-South Carolina border; and the Mint Museum, featuring American and European art. The University of North Carolina at Charlotte (UNC Charlotte) is a prominent institution. Major highways include Interstates 77 and 85, providing vital connections to other cities in the region.

16. San Francisco, California

San Francisco, located in Northern California, is known for its scenic beauty and cultural landmarks. Key landmarks include the Golden Gate Bridge, an engineering marvel; Alcatraz Island, a historic prison; and Fisherman’s Wharf, a popular tourist destination. The University of San Francisco (USF) and San Francisco State University (SFSU) are key academic institutions. Major highways include Interstates 80 and 280, facilitating travel within the Bay Area and beyond.

17. Indianapolis, Indiana

Indianapolis, located in the Midwest, is known for its motorsports and cultural attractions. Key landmarks include the Indianapolis Motor Speedway, home of the Indy 500; the Children’s Museum of Indianapolis, the largest children’s museum in the world; and the Indianapolis Museum of Art. Indiana University-Purdue University Indianapolis (IUPUI) is a notable academic institution. Major highways include Interstates 65, 69, and 70, providing critical links to other Midwestern cities.

18. Seattle, Washington

Seattle, situated in the Pacific Northwest, is known for its natural beauty and tech industry. Landmarks include the Space Needle, offering panoramic views of the city; Pike Place Market, a historic farmers market; and the Museum of Pop Culture. The University of Washington (UW) is a leading research university. Major highways include Interstates 5 and 90, connecting Seattle to other parts of Washington and the U.S.

19. Denver, Colorado

Denver, located at the base of the Rocky Mountains, is known for its outdoor recreation and cultural attractions. Key landmarks include the Denver Art Museum, featuring a vast art collection; the Colorado State Capitol, with its gold-plated dome; and the Denver Botanic Gardens. The University of Colorado Denver and the University of Denver are major institutions. Major highways include Interstates 25 and 70, providing important connections to other regions.

20. Washington, D.C.

Washington, D.C., the U.S. capital, is rich in history and political significance. Landmarks include the White House, the official residence of the President; the Capitol Building, home of the U.S. Congress; and the Smithsonian Museums, a collection of museums and research institutions. Georgetown University and George Washington University are prominent academic institutions. Major highways include Interstates 66 and 495, facilitating travel in and around the capital region.